Ghent Altarpiece Lamb
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The Ghent Altarpiece (or the Adoration of the Mystic Lamb , Dutch : Het Lam Gods ) is a very large and complex 15th-century Early Flemish polyptych altarpiece in St Bavo's Cathedral , attributed to the brothers Hubert and Jan van Eyck , and considered a masterpiece of European art and one of the world's treasures.  It is an important work in the Northern Renaissance .
It's easy to argue that the artwork is the most influential painting ever made: it was the world's first major oil painting, and is laced with Catholic mysticism. It's almost an A to Z of Christianity – from the annunciation to the symbolic sacrifice of Christ, with the "mystic lamb" on an altar in a heavenly field, bleeding into the holy grail.